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Updated: Mar 12, 2026

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus
Published on: May 13, 2021
Human herpes simplex virus: life cycle and development of inhibitors
M K Kukhanova1, A N Korovina, S N Kochetkov
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. kukhan86@hotmail.com.
Abstract:
WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.
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