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Updated: Apr 16, 2026

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
Published on: October 26, 2009
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Wei Gao1, Baoyong Sha, Yongchun Liu
1Department of Anesthesiology, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University , Xi'an , P. R. China.
Abstract:
Though starch has been a common material used for drug delivery, it has not been used as an encapsulation material for hemoglobin-based oxygen carriers. In this study, cationic amylose (CA) was synthesized by an etherification reaction. The interaction behaviors between CA and hemoglobin (Hb) were measured by zeta potential, size, and UV-Vis absorption spectra at different pH values. Cationic starch encapsulated Hb by electrostatic adhesion, reverse micelles, and cross-linking, and showed a core shell structure with a size of around 100 nm, when measured immediately after dispersing in PBS solution. However, we found that it was prone to swell, aggregate, and leak Hb with a longer duration of dispersal in PBS.
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