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Updated: Apr 16, 2026

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Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
Published on: April 17, 2012
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Macroporous silica particles derivatized for enhanced lectin affinity enrichment of glycoproteins
1Merck & Co., 126 E. Lincoln Avenue, 2000, Rahway, NJ, 07090, USA, benjamin.mann@merck.com.
Methods in Molecular Biology (Clifton, N.J.)
|March 10, 2015
Abstract:
This chapter details procedures for (1) functionalizing macroporous silica particles with lectins, a class of proteins that have affinity for the glycan moieties on glycoproteins, and (2) utilizing the lectin-silica material for high-performance affinity chromatography (HPAC) to enrich glycoproteins from small volumes of biological sample materials.

