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Related Concept Videos

Retrovirus Life Cycles01:10

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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Updated: Apr 16, 2026

A Rat Model of EcoHIV Brain Infection
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HIV eradication symposium: will the brain be left behind?

B J Brew1, K Robertson, E J Wright

  • 1Departments of Neurology, Immunology and Infectious Diseases and Peter Duncan Neurosciences Unit St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Victoria St, Darlinghurst, Sydney, Australia, 2010, B.Brew@UNSW.edu.au.

Journal of Neurovirology
|March 10, 2015
PubMed
Summary
This summary is machine-generated.

The brain may harbor HIV, posing a challenge to eradication efforts. Developing biomarkers and brain-targeting strategies are crucial for future HIV cure research.

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Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Virology

Background:

  • A symposium convened investigators in HIV eradication and HIV neurology.
  • The meeting aimed to foster dialogue on the brain as a potential HIV reservoir.

Framework:

  • Substantive, though not definitive, evidence suggests the brain acts as an HIV reservoir.
  • The brain's role as a clinically significant HIV reservoir may vary among patients.

Implementation:

  • Urgent need for biomarkers to identify and quantify brain HIV reservoirs.
  • Future HIV eradication strategies must incorporate approaches targeting the brain reservoir.

Implications:

  • Understanding the brain reservoir is critical for advancing HIV eradication.
  • Developing targeted therapies is essential for achieving a functional HIV cure.