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A case of endobronchial NUT midline carcinoma with intraluminal growth
Sho Watanabe1, Satoshi Hirano2, Sohtaro Mine3
1Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan sh.watanabe02@gmail.com.
Background:
NUT midline carcinoma (NMC) is a rare, lethal form of differentiated squamous cell carcinoma characterized by chromosomal rearrangement of the NUT gene. Its highly aggressive nature commonly leads to unresectable and metastatic lesions.
Case Report:
We report on a case of endobronchial NMC in a middle-aged man who was treated by bronchoscopic electrocautery followed by Ewing sarcoma-based chemotherapy with concurrent chemoradiotherapy. The patient's disease continued to be stable 31 months after diagnosis.
Review:
NMC is a challenging disease entity, which is difficult to diagnose and treat, and has a dismal overall survival. Most cases of NMC are widely metastatic or unresectable when diagnosed.
Discussion:
This is the first reported case that involves intraluminal tumour growth of NMC and demonstrates the effectiveness of early intensive local therapy aided by bronchoscopic techniques.
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