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Updated: Apr 16, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Proton beam therapy combined with concurrent chemotherapy for esophageal cancer
Hitoshi Ishikawa1, Takayuki Hashimoto2, Toshikazu Moriwaki3
1Department of Radiation Oncology, University of Tsukuba, Faculty of Medicine, Ibaraki, Japan hishikawa@pmrc.tsukuba.ac.jp.
Background/Aim:
The aim of the present study was to evaluate the outcomes of proton beam therapy (PBT) concurrently combined with chemotherapy consisting of cisplatin and 5-fluorouracil for esophageal cancer.
Patients And Methods:
Forty consecutive patients (stage I in 16 patients, II in 9 and III in 15) treated between 2008 and 2012 were evaluated. A total dose of 60 Gray equivalents (GyE) in 30 fractions was delivered, and an additional boost of 4-10 GyE was given when residual tumors were suspected. The median follow-up time was 24 months (range=7-66 months).
Results:
No cardio-pulmonary toxicities of grade 3 or higher were observed. Recurrences were observed in 16 patients, and the 2-year rates of disease-specific survival and locoregional control were 77% and 66%, respectively.
Conclusion:
Irrespective of the small sample size and short follow-up time of the study, proton beam therapy combined with chemo therapy seems to be feasible for esophageal cancer.
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