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Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
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Dye-Staining Angioscopy for Coronary Artery Disease
Yasumi Uchida1, Yasuto Uchida2
1Japanese Foundation for Cardiovascular Research, 2-30-17, Narashinodai, Funabashi, 274-0063 Japan ; Department of Cardiology, The Jikei University School of Medicine, Tokyo, Japan.
Current Cardiovascular Imaging Reports
|March 10, 2015
Summary
Novel imaging techniques reveal that fibrin, not platelets, often causes acute coronary syndrome and restenosis. Dye-staining angioscopy visualizes these fibrin thrombi and microcirculation in real-time.
Area of Science:
- Cardiovascular Imaging
- Biomarker Discovery
- Medical Diagnostics
Background:
- Coronary artery disease (CAD) mechanisms were poorly understood.
- Existing imaging lacked detail on thrombus composition and microcirculation.
Approach:
- Utilized dye-staining coronary angioscopy with Evans blue (EB) for fibrin visualization.
- Employed fluorescent angioscopy for molecular imaging of plaque components.
- Applied dye-staining cardioscopy for subendocardial microcirculation assessment.
Key Points:
- Identified fibrin-rich thrombi as frequent culprits in acute coronary syndrome (ACS), challenging the platelet-thrombus theory.
- Demonstrated fibrin threads causing "fluffy" surfaces and web-like thrombi in stent restenosis.
- Showcased EB and fluorescein angioscopy for real-time visualization of thrombi and microcirculation.
Conclusions:
- Novel biomarker imaging clarifies CAD pathogenesis and evaluates blood flow.
- Dye-staining angioscopy provides critical insights into thrombus composition and ACS mechanisms.
- Advanced angioscopy techniques enable precise molecular imaging and microcirculation assessment in CAD.
Keywords:
AngioscopyApolipoproteinsBiomarkersCardioscopyCholesterolLipoproteinsMyocardial tissue fluid flowSubendocardial myocardial blood flowMore Related Videos
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