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Updated: Apr 16, 2026
05:26
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
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Endogenous Cardioprotective Agents: Role in Pre and Postconditioning.
Claudia Penna, Riccarda Granata, Carlo Gabriele Tocchetti
1Department of Clinical and Biological Sciences, University of Torino, Orbassano (TO), Italy. pasquale.pagliaro@unito.it.
Current Drug Targets
|March 10, 2015
Summary
Cardioprotection strategies like conditioning protocols can mitigate heart damage from ischemia and reperfusion injury. These methods activate endogenous protective factors, offering potential for new heart attack therapies.
Area of Science:
- Cardiology
- Molecular Biology
- Biochemistry
Background:
- Cardiovascular diseases (CVD) are a leading cause of mortality globally.
- Acute myocardial ischemia and reperfusion injury are primary contributors to CVD.
- Cardioprotection strategies are crucial for mitigating heart damage.
Purpose of the Study:
- To review endogenous cardioprotective factors and pathways.
- To highlight mechanisms of action for various cardioprotective agents.
- To discuss the clinical translation of cardioprotection strategies.
Main Methods:
- Literature review of endogenous cardioprotective agents.
- Analysis of conditioning protocols (pre-, post-, and remote).
- Examination of factors like chromogranin A derivatives, ghrelin peptides, growth factors, cytokines, microvesicles, exosomes, and gasotransmitters.
Main Results:
- Conditioning protocols (pre-, post-, remote) induce endogenous cardioprotective responses.
- Various endogenous factors, including peptides, proteins, and gasotransmitters, mediate cardioprotection.
- Specific mechanisms involve cytoprotective pathways activated by these factors.
Conclusions:
- Endogenous cardioprotective strategies offer promising therapeutic avenues for myocardial infarction.
- Understanding these factors' mechanisms is key to developing novel cardioprotection therapies.
- Clinical translation of these findings could significantly advance cardiovascular medicine.
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