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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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AMPK modulates Hippo pathway activity to regulate energy homeostasis

Wenqi Wang1, Zhen-Dong Xiao1, Xu Li1

  • 1Department of Experimental Radiation Oncology, 1515 Holcombe Boulevard Houston, Texas 77030, USA.

Nature Cell Biology
|March 10, 2015
PubMed
Summary

Glucose metabolism regulates the Hippo pathway, a key tumor suppressor. Glucose starvation activates the Hippo pathway and AMP-activated protein kinase (AMPK), inactivating YAP and impacting cancer prevention.

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