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Updated: Apr 16, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
Series of paraneoplastic vasculitic neuropathy: a rare, potentially treatable neuropathy
Meena A Kannan1, Sundaram Challa, Rukmini M Kandadai
1Department of Neurology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India.
Background:
Paraneoplastic vasculitic neuropathy (PVN) is a rare paraneoplastic syndrome. It is characterized by non-systemic subacute vasculitic neuropathy. It is most commonly associated with small cell lung cancers (SCLC) and lymphomas. PVN presents as a painful symmetrical or asymmetrical sensorimotor axonal neuropathy. The neurological symptoms may predate the tumor and may be the initial manifestations, or they may develop after a tumor is diagnosed. Recognition of this entity is important because of its potential treatability.
Aim:
To study the clinical features of PVN and briefly review the literature.
Materials And Methods:
The data was collected retrospectively from the medical records of our hospital.
Results:
Of the 14 cases of paraneoplastic neuropathies, 4 had a PVN. The age of onset was more than 50 years and there was no sex preponderance. Pain was seen in three patients. Two patients were previously treated for a thymoma. Two patients, following their presentation with PVN, were diagnosed with a colonic carcinoma and lung carcinoma, respectively.
Conclusions:
The recognition of PVN is important as this syndrome may respond to immunosuppression and tumor removal.
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