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Updated: Apr 16, 2026

Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica
Published on: August 31, 2011
[Study of possible involvement of MEK mitogen-activated protein kinase and TGF-β receptor in planarian regeneration
Abstract:
Possible involvement of MEK mitogen-activated protein kinase and TGF-β receptor in the processes of regeneration and morphogenesis in freshwater planarian flatworms Schmidtea mediterranea was studied using a pharmacological inhibitor analysis. It was found that pharmacological inhibitors of these kinases significantly inhibit the regeneration of the head end of the animals and that this effect is realized due to inhibition of proliferative activity of neoblasts, planarian stem cells. It is shown that that the inhibition of the studied protein kinases in regenerating planarians markedly disturbs stem cell differentiation and morphogenesis.
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