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Related Experiment Video

Updated: Apr 16, 2026

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

Published on: June 16, 2023

Peritoneal metastases: challenges for the surgeon.

D Baratti¹, S Kusamura, M Guaglio

¹Peritoneal Malignancy Program, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy - dario.baratti@istitutotumouri.mi.it.

Minerva Chirurgica

|March 11, 2015

Summary

This summary is machine-generated.

Peritoneal surface malignancies (PSM) are now viewed as a local-regional disease stage. Combining cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) offers improved survival for select patients.

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Area of Science:

Surgical Oncology
Medical Oncology
Gastroenterology

Background:

Peritoneal surface malignancies (PSM) were historically considered end-stage, palliative-only conditions.
Recent understanding reframes PSM as a local-regional disease stage, amenable to curative-intent treatment.
This shift necessitates a review of advanced treatment modalities.

Purpose of the Study:

To review current literature on the surgical and comprehensive management of PSM.
To discuss the epidemiology, natural history, and evolving treatment concepts for PSM.
To detail cytoreductive surgery (CRS) and intraperitoneal chemotherapy techniques for PSM.

Main Methods:

Review of recent literature on PSM management.
Description of cytoreductive surgery (CRS) procedures.
Explanation of perioperative intraperitoneal chemotherapy techniques (HIPEC and early postoperative chemotherapy).

Main Results:

Combined CRS and HIPEC demonstrates survival improvements over historical controls for selected PSM.
This multimodal approach is increasingly accepted as a standard of care.
Outcomes for specific PSM types (appendiceal, colorectal, gastric, ovarian, primary peritoneal) are addressed.

Conclusions:

PSM management has evolved from palliative care to aggressive, curative-intent strategies.
CRS combined with HIPEC represents a significant advancement in treating PSM.
Further research and standardization of CRS/HIPEC for various PSM are warranted.