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Updated: Apr 16, 2026
07:30
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
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Kidney function and cerebral small vessel disease in the general population
Saloua Akoudad1,2,3, Sanaz Sedaghat1, Albert Hofman1
1Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Summary
Worse kidney function is linked to cerebral small vessel disease. Higher albumin-to-creatinine ratio, a marker of kidney damage, is particularly associated with brain small vessel disease.
Area of Science:
- Nephrology and Neurology
- Cardiovascular and Metabolic Research
Background:
- Renal and cerebral vessels share similarities, suggesting a connection between kidney and brain diseases.
- Existing markers for kidney and brain disease lack comprehensive assessment of their interrelationship.
Purpose of the Study:
- To determine if kidney function measures correlate with cerebral small vessel disease (CSVD) detected via MRI.
- Investigate the association between markers of kidney function and indicators of brain small vessel disease.
Main Methods:
- Utilized data from 2526 participants in the population-based Rotterdam Study.
- Assessed kidney function using urinary albumin-to-creatinine ratio and estimated glomerular filtration rate (eGFR) from creatinine and cystatin C.
- Evaluated cerebral small vessel disease through brain MRI, measuring white matter lesion volumes, lacunes, and cerebral microbleeds.
Main Results:
- Poorer kidney function correlated with increased white matter lesion volume.
- Higher albumin-to-creatinine ratio and lower cystatin C-based eGFR were linked to a greater prevalence of lacunes.
- Increased albumin-to-creatinine ratio was associated with a higher frequency of microbleeds.
Conclusions:
- Reduced kidney function is associated with cerebral small vessel disease.
- Albumin-to-creatinine ratio emerged as a significant indicator linking kidney function to cerebral small vessel disease.
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