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Circulating endothelial cells in coronary artery disease and acute coronary syndrome

David E Schmidt1, Marco Manca2, Imo E Hoefer3

  • 1University Medical Center Utrecht, Maastricht, The Netherlands.

Trends in Cardiovascular Medicine
|March 11, 2015
PubMed

Insights

Circulating endothelial cells (CECs) show promise as biomarkers for cardiovascular diseases. Further research into improved counting methods and large-scale studies is needed to confirm their clinical value.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Cellular Biology

Background:

  • Circulating endothelial cells (CECs) are recognized as potential biomarkers for diagnosing and predicting coronary artery disease and acute coronary syndromes.
  • Understanding the physiology and pathobiology of CECs, including their interactions with endothelial progenitor cells and microparticles, is crucial.

Purpose of the Study:

  • To review current knowledge on CECs as cardiovascular biomarkers.
  • To explore advancements in CEC quantification, morphology, transcriptomics, and proteomics for improved diagnostic and prognostic value.
  • To highlight the need for standardized methods and further research.

Main Methods:

  • Comprehensive literature review of studies on circulating endothelial cells.
  • Analysis of current insights into CEC physiology, pathobiology, and quantification methods.
  • Evaluation of emerging techniques for CEC characterization.

Main Results:

  • CECs hold significant potential as diagnostic and prognostic indicators for cardiovascular conditions.
  • Current quantification methods require improvement and a consensus on cell definition is lacking.
  • Integrating CEC morphology, transcriptomics, and proteomics may enhance their utility.

Conclusions:

  • Standardized counting methods and a validated CEC definition are essential for clinical application.
  • Large-scale, population-based prospective studies are necessary to establish the definitive clinical value of CECs in cardiovascular medicine.

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