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Modified vibrating-mesh nozzles for advanced spray-drying applications.

Moritz Beck-Broichsitter1, Ilka E Paulus2, Andreas Greiner2

  • 1Medical Clinic II, Department of Internal Medicine, Justus-Liebig-Universität, Giessen, Germany; Department of Pharmaceutics and Biopharmacy, Philipps-Universität, Marburg, Germany.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|March 11, 2015
PubMed
Summary

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Uniform polymer coatings precisely control nozzle dimensions in spray-drying. This innovation enables fine-tuning droplet and microparticle sizes for diverse applications, enhancing formulation atomization and drug delivery.

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmaceutical Technology

Background:

  • Vibrating-mesh nozzles are crucial for spray-drying applications, influencing droplet and particle size.
  • Controlling orifice dimensions is key to achieving desired formulation characteristics.

Purpose of the Study:

  • To investigate the use of uniform polymer coatings to adjust vibrating-mesh nozzle orifice dimensions.
  • To evaluate the impact of these coatings on droplet and microparticle size in spray-drying.
  • To assess the effect on drug release profiles.

Main Methods:

  • Chemical vapor deposition of poly(p-xylylene) (PPXN) was used to coat nozzle aperture templates.
  • Spray-drying of sildenafil-loaded poly(lactide-co-glycolide) formulations using coated and uncoated nozzles.
Keywords:
Chemical vapor depositionControlled drug deliveryParylene coatingPolymeric microparticlesSpray-dryingVibrating-mesh atomization

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  • Particle size analysis and in vitro drug release studies were performed.

    • Main Results:

    • PPXN coatings reduced nozzle orifice cross-sections by approximately 50%, leading to finer droplets.
    • PPXN-coated nozzles produced significantly smaller (1.3 μm vs. 3.6 μm) and more uniformly distributed microparticles.
    • The "residual core method" accurately predicted microparticle size based on droplet size.
    • Sustained drug release was observed, with PPXN-coated nozzles resulting in longer mean dissolution times (4.0 h vs. 1.5 h).

    Conclusions:

    • Uniform polymer coatings offer a versatile method for precisely controlling nozzle orifice dimensions in spray-drying.
    • This technique allows for tailored production of microparticles with desired sizes and release characteristics.
    • The findings have broad implications for optimizing diverse spray-drying applications.