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Osteoblast differentiation profiles define sex specific gene expression patterns in craniosynostosis.

Sarah S Park1, Richard P Beyer2, Matthew D Smyth3

  • 1Seattle Children's Research Institute, Center for Developmental Biology and Regenerative Medicine, Seattle, WA, USA.

Bone
|March 11, 2015
PubMed
Summary

Single suture craniosynostosis (SSC) involves premature fusion of skull sutures. This study found osteoblast dysfunction in SSC, with sex-specific gene expression patterns contributing to the condition.

Keywords:
CraniosynostosisGene expression analysisOsteoblast differentiationOsteoblasts

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