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Updated: Apr 16, 2026

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy
Published on: January 7, 2019
Analog time-reversed ultrasonically encoded light focusing inside scattering media with a 33,000× optical power gain
Cheng Ma1, Xiao Xu1, Lihong V Wang1
1Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130-4899, USA.
Abstract:
Recent breakthrough in wavefront engineering shows great promises in controlling light propagation inside scattering media. At present, the digital approaches enjoy high gain, while their speeds are slow because of high data throughputs. In contrast, the analog approaches are intrinsically fast but suffer from poor efficiencies and small gains. Further improvements in both speed and gain are necessary to advance the existing technologies toward real-world applications. Here, we report analog time-reversal of acousto-optically tagged photons with a flux amplification of over 33,000 times (45 dB) at a target location inside scattering media. Such a substantial power gain enhancement is achieved when the temporal width of the time-reversed photon packet is squeezed below the carrier-recombination-limited hologram decay time in a photorefractive crystal. Despite a focusing energy gain below unity, the unprecedented power gain is expected to enable new optical imaging, sensing, manipulation and treatment applications.

