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Prognostic value of long noncoding RNA HOTAIR in digestive system malignancies
1Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Journal of Gastroenterology and Hepatology
|March 11, 2015
Summary
High expression of HOTAIR long noncoding RNA indicates poor survival in digestive system cancers. This meta-analysis confirms HOTAIR as a reliable prognostic biomarker for these malignancies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- HOX transcript antisense intergenic RNA (HOTAIR) is a long noncoding RNA implicated in various cancers.
- The prognostic value of HOTAIR in digestive system malignancies requires further clarification.
Purpose of the Study:
- To comprehensively evaluate the potential of HOTAIR as a prognostic indicator in digestive system cancers.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, Embase, Cochrane Library, Web of Science) up to July 2014.
- A quantitative meta-analysis was performed on 13 eligible studies, including 1059 patients, to assess the prognostic value of HOTAIR.
Main Results:
- HOTAIR abundance was significantly associated with poor overall survival (OS) in digestive system malignancies (pooled HR: 2.587).
- HOTAIR was identified as an independent prognostic factor for OS across various subgroups, with consistent predictive value.
- Sensitivity and meta-regression analyses confirmed the reliability of findings, with minimal impact from publication bias after adjustment.
Conclusions:
- HOTAIR serves as a novel and reliable prognostic biomarker for patients diagnosed with digestive system malignancies.
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