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Is migraine a risk factor for pediatric stroke?

Amy A Gelfand1, Heather J Fullerton2, Alice Jacobson3

  • 1UCSF Headache Center, Department of Neurology, University of California San Francisco, USA Division of Child Neurology, UCSF, USA GelfandA@neuropeds.ucsf.edu.

Cephalalgia : an International Journal of Headache
|March 11, 2015
PubMed

Insights

Pediatric migraineurs did not show a significant increase in stroke risk. However, adolescents with migraine experienced a higher risk of ischemic stroke, warranting further investigation into risk factors.

Area of Science:

  • Neurology
  • Pediatrics
  • Epidemiology

Background:

  • Childhood stroke risk factors remain incompletely understood.
  • Migraine with aura is a known risk factor for ischemic stroke in adults.

Purpose of the Study:

  • To investigate the association between migraine and stroke in children.
  • To determine if migraine increases stroke risk in pediatric populations.

Main Methods:

  • A cohort study was conducted using data from Kaiser Permanente Northern California (KPNC) from 1997-2007.
  • Included were children aged 2-17 years with diagnosed migraine or no headache history.
  • Stroke incidence rates and incidence rate ratios were calculated.

Main Results:

  • No statistically significant increase in hemorrhagic or ischemic stroke was observed in pediatric migraineurs overall.
  • A post-hoc analysis revealed a significantly elevated risk of ischemic stroke in adolescents (12-17 years) with migraine (IR 3.4).
  • Hemorrhagic stroke incidence was lower in migraineurs compared to controls.

Conclusions:

  • Migraine is not associated with a significant increase in overall stroke risk in children.
  • Adolescents with migraine may have an elevated risk for ischemic stroke.
  • Future research should explore risk factors for ischemic stroke in adolescent migraineurs, including migraine aura.
Abstract

Keywords:
Migraineaurachildhood strokepediatric stroke

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