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[Severe acute kidney injury in critically ill children: Epidemiology and prognostic factors]

P Touza Pol1, C Rey Galán2, J A Medina Villanueva3

  • 1Unidad de Cuidados Intensivos Pediátricos, Hospital Madrid Torrelodones, Torrelodones, Madrid, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|March 11, 2015
PubMed

Insights

Acute kidney injury (AKI) in critically ill children leads to high mortality and morbidity. Platelet count and creatinine clearance predict the need for renal replacement therapy (RRT) and survival outcomes.

Area of Science:

  • Pediatric Nephrology
  • Critical Care Medicine
  • Epidemiology

Background:

  • Acute kidney injury (AKI) is a significant complication in pediatric intensive care units (PICUs).
  • Understanding AKI's characteristics and prognostic factors is crucial for critically ill children.

Purpose of the Study:

  • To describe AKI characteristics in Spanish PICUs.
  • To identify prognostic factors for mortality and renal replacement therapy (RRT) in pediatric AKI patients.

Main Methods:

  • Prospective, observational, multicenter study.
  • Included children aged 7 days to 16 years admitted to PICUs.
  • Logistic regression analysis for mortality and RRT risk factors.

Main Results:

  • 139 AKI cases analyzed; 60.1% required RRT.
  • Mortality rate was 32.6%; 15% of survivors needed RRT at discharge.
  • Low platelet count and creatinine clearance predicted RRT need; high platelets, creatinine, and weight associated with better survival.

Conclusions:

  • Critically ill children with AKI face high mortality and morbidity.
  • Platelet count and creatinine clearance are key indicators for RRT and survival in pediatric AKI.
Abstract

Keywords:
Acute kidney injuryDaño renal agudoDepuración extrarrenalMortalidadMortalityOutcomePaediatric Intensive Care UnitsPronósticoRenal replacement therapyUnidades de Cuidados Intensivos Pediátricos

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