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Natriuretic Peptides as a Novel Target in Resistant Hypertension
1Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Abstract:
Resistant hypertension is defined as blood pressure not under goal despite being on at least three antihypertensives. Resistant hypertension is associated with significant cardiovascular morbidity and mortality. Currently, the mainstay for the treatment of resistant hypertension is lifestyle modification and antihypertensive drugs. Natriuretic peptides play an important role in regulating cardiovascular hemodynamics and sodium and fluid homeostasis including blood pressure control. They hold a promising potential for treatment of resistant hypertension.
Related Concept Videos
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Drugs: Direct Renin Inhibitors
Heart Failure Drugs: Diuretics
Antihypertensive Drugs: Angiotensin II Receptor Blockers

