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Chronic urticaria due to autoreactivity to progesterone
L Wingate-Saul1, J Rymer1, M W Greaves1
1Guy's and St Thomas' NHS Foundation Trust, London, UK.
Clinical and Experimental Dermatology
|March 11, 2015
Summary
Premenstrual urticaria, a rare progesterone allergy, was effectively treated with goserelin (Zoladex) to suppress the menstrual cycle. This treatment induced remission, but long-term alternatives may be needed due to risks of artificial menopause.
Area of Science:
- Immunology
- Gynecology
- Dermatology
Background:
- Premenstrual urticaria is a rare condition linked to hormonal fluctuations.
- Standard treatments for urticaria are often ineffective for hormonally triggered cases.
Observation:
- A 23-year-old woman experienced recurrent premenstrual urticarial eruptions.
- Skin prick testing confirmed a positive reaction to progesterone.
Findings:
- Treatment with goserelin (Zoladex) suppressed the menstrual cycle, resolving the patient's urticaria.
- The patient achieved remission with continued goserelin injections, indicating efficacy in managing progesterone-induced urticaria.
Implications:
- Goserelin offers a potential therapeutic option for severe, treatment-resistant premenstrual urticaria.
- The induction of temporary menopause necessitates careful consideration of long-term management strategies and potential risks.
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