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Habitual coffee intake, genetic polymorphisms, and type 2 diabetes.
Jae Kyung Lee1, Kyunga Kim1, Younjhin Ahn1
1Department of Food and NutritionSookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul 140-742, Republic of KoreaBiostatistics and Clinical Epidemiology CenterSamsung Medical center, 50 Ilwon-dong, Gangnam-gu, Seoul 135-170, Republic of KoreaDivision of Cardiovascular and Rare DiseaseNational Institute of Health, Centers of Biomedical Sciences, Center for Disease Control and Prevention, Chungcheongbuk-do, Republic of KoreaResearch Center for Cell Fate controlCollege of Pharmacy, Sookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul 140-742, Republic of Korea.
Coffee consumption may lower type 2 diabetes risk, especially for individuals with specific genetic variations in IGF2BP2, CDKAL1, and KCNJ11. These findings highlight the role of genetics in the coffee-diabetes association.
Area of Science:
- Endocrinology
- Nutritional Epidemiology
- Human Genetics
Background:
- The relationship between coffee consumption and type 2 diabetes risk may be influenced by genetic factors.
- Understanding these genetic modulations is crucial for personalized diabetes prevention strategies.
Purpose of the Study:
- To investigate the association between habitual coffee intake and the risk of developing type 2 diabetes.
- To determine if genetic polymorphisms influence the coffee-diabetes association in Korean adults.
Main Methods:
- A 4-year population-based cohort study of 4077 Korean adults (40-69 years) with normal baseline glucose levels.
- Coffee intake assessed via food frequency questionnaire; type 2 diabetes/prediabetes diagnosed by oral glucose tolerance or fasting blood glucose tests.
- Genotyping of nine type 2 diabetes-associated single-nucleotide polymorphisms (SNPs) in East Asian populations.
Main Results:
- An inverse association was observed between coffee intake and the combined risk of type 2 diabetes and prediabetes.
- This inverse association was significant in individuals carrying specific alleles for IGF2BP2 (rs4402960 T-allele), CDKAL1 (rs7754840 G-allele), and KCNJ11 (rs5215 CC genotype).
Conclusions:
- Coffee intake is associated with a reduced risk of prediabetes and type 2 diabetes in individuals with specific genetic profiles.
- Genetic variations in IGF2BP2, CDKAL1, and KCNJ11 modify the protective effect of coffee against type 2 diabetes in the East Asian population.
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