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Association between Celiac Disease and Chronic Hepatitis C Virus Infection
Ashish Garg1, Chandrasekhar Reddy1, Ajay Duseja1
1Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Journal of Clinical and Experimental Hepatology
|March 11, 2015
Summary
Celiac disease, an autoimmune disorder triggered by gluten, can present with various symptoms. This study found no causal link between celiac disease and chronic hepatitis C infection.
Area of Science:
- Gastroenterology
- Hepatology
- Immunology
Background:
- Celiac disease is an immune response to gluten affecting the small intestine.
- It can manifest with chronic diarrhea, elevated liver enzymes, or iron-deficiency anemia.
- Celiac disease is linked to autoimmune liver diseases, and Hepatitis C Virus (HCV) can trigger autoimmunity.
Purpose of the Study:
- To investigate the potential association between celiac disease and chronic Hepatitis C Virus (HCV) infection.
- To explore if HCV infection and celiac disease frequently co-occur.
Main Methods:
- Case series describing four patients with both celiac disease and chronic hepatitis C.
- Review of clinical presentations and diagnostic findings.
Main Results:
- Four cases of concurrent celiac disease and chronic hepatitis C were identified.
- The case series suggests no direct causal relationship between the two conditions.
Conclusions:
- Chronic Hepatitis C virus infection and celiac disease are not causally linked.
- Further research may be needed to understand the co-occurrence of these conditions.
Keywords:
AEA, anti-endomysial antibodiesAGA, antigliadin antibodiesALT, alanine aminotransferaseAST, aspartate aminotransferaseAutoimmune diseaseHBsAg, hepatitis B surface antigenHCV, hepatitis C virusHLA, human leukocyte antigenIg, immunoglobulinRNA, ribonucleic acidWBC, white blood cellceliac diseasehepatitis C virus infectionMore Related Videos
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