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Quo vadis: from oxidative stress to gamma-glutamyltransferase upregulation to mortality

Rohini Mehta1, Aybike Birerdinc1, Zobair Younossi1

  • 1Betty and Guy Beatty Obesity and Liver Program, Inova Health System, Falls Church, VA, USA.

Journal of Clinical and Experimental Hepatology
|March 11, 2015
PubMed
Abstract

No abstract available in PubMed .

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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