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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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Autophagy modulation as a potential therapeutic target for liver diseases

Pankaj Puri1, Alok Chandra2

  • 1Department of Gastroenterology, Army Hospital (Research and Referral), Dhaula Kuan, New Delhi 110010, India.

Journal of Clinical and Experimental Hepatology
|March 11, 2015
PubMed
Summary

Autophagy is a vital cellular process for removing damaged components and pathogens, crucial for preventing cell death and maintaining health. Modulating autophagy shows therapeutic promise for liver diseases.

Keywords:
AMPk, adenosine monophosphate-activated protein linaseAT, antitrypsinER, endoplasmic reticulumHBV, hepatitis B virusHCC, hepatocellular carcinomaHCV, hepatitis C virusHSC, hepatic stellate cellsNASH, Non Alcoholic Steato-HepatitisSTEBPs, sterol regulatory element-binding proteinsTG, triglycerideULK1, Uncoordinated 51-like kinase 1autophagosomeautophagyliver diseasesmTORC1, mTOR complex 1mTORC2, mTOR complex 2

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