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Terbinafine induced liver injury: a case report
Narendra S Choudhary1, Hardik Kotecha2, Neeraj Saraf1
1Institute of Liver Transplantation and Regenerative Medicine, Medanta, The Medicity, Sector 38, Gurgaon, Haryana, India.
Journal of Clinical and Experimental Hepatology
|March 11, 2015
Summary
Drug-induced liver injury (DILI) can cause significant illness. This case highlights a rare instance of terbinafine-induced liver injury, specifically hepatitis-cholestatic injury, with a lengthy three-month recovery period after drug cessation.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Toxicology
Background:
- Drug-induced liver injury (DILI) is a significant cause of morbidity.
- Prompt diagnosis of DILI is crucial and necessitates a high index of suspicion.
- Terbinafine is an antifungal medication with a known, albeit rare, risk of hepatotoxicity.
Purpose of the Study:
- To report a rare case of terbinafine-induced liver injury.
- To characterize the clinical presentation and recovery course of terbinafine-induced hepatitis-cholestatic injury.
- To emphasize the importance of considering DILI in patients presenting with liver abnormalities.
Main Methods:
- Case report presentation.
- Review of clinical history, laboratory findings, and diagnostic workup.
- Monitoring of patient's recovery after drug discontinuation.
Main Results:
- The patient developed hepatitis-cholestatic injury attributed to terbinafine.
- A prolonged recovery phase of three months was observed after discontinuing the medication.
- The injury pattern was cholestatic, indicating bile flow impairment.
Conclusions:
- Terbinafine can cause rare but severe liver injury, including cholestatic hepatitis.
- A high index of suspicion is necessary for timely diagnosis of DILI.
- Prolonged recovery may be a feature of certain DILI cases, such as this terbinafine-induced injury.
