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Low expression of long non-coding RNA LET inhibits carcinogenesis of cervical cancer

Shan Jiang1, Hui-Ling Wang1, Jun Yang1

  • 1Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Henan, P.R. China.

International Journal of Clinical and Experimental Pathology
|March 11, 2015
PubMed
Abstract

Insights

The long non-coding RNA LET (lncRNA LET) is down-regulated in cervical cancer tissues, correlating with advanced disease stages and poorer survival. This suggests lncRNA LET could be a prognostic marker for cervical cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are implicated in tumorigenesis.
  • The lncRNA LET is frequently downregulated in various cancers.
  • The role of lncRNA LET in human cervical cancer remains largely uncharacterized.

Purpose of the Study:

  • To investigate the clinical significance of lncRNA LET expression in cervical cancer.
  • To determine the correlation between lncRNA LET expression and clinicopathological features.
  • To evaluate lncRNA LET as a prognostic biomarker for cervical cancer patients.

Main Methods:

  • Quantitative real-time PCR was used to examine lncRNA LET expression.
  • Expression levels were analyzed in 94 cervical cancer tissues and matched adjacent non-tumor tissues.
  • Statistical analyses correlated lncRNA LET expression with clinicopathological features and patient survival.

Main Results:

  • lncRNA LET expression was significantly downregulated in cervical cancer tissues compared to non-tumor tissues (P < 0.05).
  • Reduced lncRNA LET expression correlated significantly with advanced FIGO stage, lymph node metastasis, and depth of invasion (P < 0.05).
  • Lower lncRNA LET expression was associated with significantly poorer overall survival in cervical cancer patients (P < 0.05).

Conclusions:

  • lncRNA LET expression is significantly decreased in cervical cancer.
  • lncRNA LET serves as an independent prognostic predictor for overall survival in cervical cancer.
  • lncRNA LET may represent a potential therapeutic target and prognostic marker for cervical cancer.
Keywords:
cervical cancerlncRNA LETprognosisquantitative real-time PCR

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