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Updated: Apr 16, 2026

Transuterine Fetal Tracheal Occlusion Model in Mice
Published on: February 5, 2021
Intestinal perforation in the context of thoracoamniotic shunting and congenital diaphragmatic hernia
Theodore Dassios1, Wassim A Hassan2, Marcin Kazmierski3
1Neonatal Intensive Care Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Abstract:
A fetus was diagnosed by prenatal ultrasound with bilateral intrauterine pleural effusions that were subsequently drained in utero by insertion of bilateral thoracoamniotic shunts. Serial prenatal ultrasound scans were consistent with a left-sided diaphragmatic hernia. On the first day of life, the infant underwent an exploratory laparotomy for intestinal obstruction, with radiographic findings of pneumatosis intestinalis. Intraoperative findings were suggestive of prenatal bowel and diaphragm perforation, which might have occurred as a complication of thoracoamniotic shunting.
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