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Related Experiment Videos

[Gastric microflora in patients receiving H2-blocker].

N Kato, K Watamabe, K Ueno

    Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
    |July 1, 1989
    PubMed
    Summary

    Histamine H2-receptor antagonists (H2-blockers) increase gastric pH, promoting aerobic and anaerobic bacterial overgrowth. This suggests a potential risk for pathogens causing aspirate pneumonia in patients using these medications.

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    Area of Science:

    • Microbiology
    • Gastroenterology
    • Pharmacology

    Background:

    • Histamine H2-receptor antagonists (H2-blockers) are commonly prescribed to reduce gastric acid.
    • Altered gastric pH can significantly impact the composition of gastric microflora.

    Purpose of the Study:

    • To investigate the effects of H2-blocker therapy on gastric microflora composition and pH.
    • To assess the potential for bacterial overgrowth and pathogenic implications.

    Main Methods:

    • Gastric aspirates were analyzed for microflora in 21 patients receiving H2-blockers and in a control group.
    • Gastric pH levels were measured and correlated with bacterial counts (aerobic and anaerobic).

    Main Results:

    • H2-blocker use led to elevated gastric pH (mean 4.32, range 1.91-6.51), with 10 cases exceeding pH 5.00.

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  • Aerobic bacteria (95%) and anaerobic bacteria (33%) were frequently isolated, with counts correlating positively with pH.
  • Candida (82%) and Staphylococcus (41%) were predominant isolates; Fusobacterium was present (33%), but Bacteroides fragilis group was absent.

    • Conclusions:

    • H2-blocker therapy promotes the overgrowth of both aerobic and anaerobic bacteria in the stomach.
    • This altered gastric environment may increase the risk of opportunistic infections, such as aspirate pneumonia, due to pathogenic bacteria.