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Published on: January 13, 2017
Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers
Leslie Boudesocque-Delaye1, Daniel Agostinho1, Charles Bodet2
1†Equipe Recherche et Innovation en Chimie Médicinale, UMR INRA 1282 Infectiologie et Santé Publique, Université de Tours François Rabelais, 37200 Tours, France.
Abstract:
Two heterodimers comprising anthraquinone and methylbenzoisocoumarin moieties (1 and 2) were isolated, together with emodin and physcion from the tubers of Pyrenacantha kaurabassana. The structures of 1 and 2 were established by NMR spectroscopy, including the analysis of a 2D INADEQUATE spectrum. On the basis of the data obtained, the structures that were previously proposed in the literature for these compounds were revised. Compounds 1 and 2 showed antibacterial activity against three different strains of Staphylococcus aureus. Compound 2 also showed bactericidal activity against Helicobacter pylori.
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