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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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Catalytic enantioselective allenoate-alkene [2 + 2] cycloadditions.

Michael L Conner1, Yao Xu1, M Kevin Brown1

  • 1Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, Indiana 47405, United States.

Journal of the American Chemical Society
|March 11, 2015
PubMed
Summary

This study introduces a new catalytic enantioselective [2 + 2] cycloaddition method using allenoates and alkenes. The process efficiently creates chiral products, notably accommodating unactivated alkenes, a significant advancement in the field.

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