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Patch testing custom isocyanate materials from the workplace.

Dianne Burrows1, Marie-Claude Houle, D Linn Holness

  • 1From the *Queen's University, Kingston; †Department of Occupational and Environmental Health, St Michael's Hospital, Toronto, Ontario; ‡Division of Dermatology, Department of Medicine, Hotel-Dieu de Québec, Université Laval, Québec City, Québec; §Dalla Lana School of Public Health, and ∥Department of Medicine, University of Toronto, Ontario, Canada.

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Summary

Custom patch testing with workplace isocyanate products is valuable for diagnosing allergic contact dermatitis (ACD). This method identified reactions in 27% of patients, including those negative to standard allergen trays.

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Area of Science:

  • Dermatology
  • Occupational Health
  • Allergology

Background:

  • Standard patch testing uses commercial allergens for suspected isocyanate-induced allergic contact dermatitis (ACD).
  • Some clinics supplement standard testing with custom isocyanate preparations.

Purpose of the Study:

  • To evaluate the added value of custom isocyanate patch testing in suspected ACD cases.

Main Methods:

  • Retrospective analysis of 11 patients with suspected ACD.
  • Patients underwent patch testing with both standard allergen trays and custom workplace isocyanate materials.

Main Results:

  • 27% (3/11) of patients showed added value from custom isocyanate testing.
  • Two patients (18%) had positive reactions only to custom materials, not standard ones.

Conclusions:

  • Custom patch testing with workplace isocyanate products is recommended.
  • It serves as a valuable supplement to standard patch testing for ACD diagnosis.