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CD 15 antigen in Hodgkin's disease
T Petrella1, J F Michiels, R Michiels
1Laboratoire d'Anatomie Pathologique, Faculté de Médecine, Dijon, France.
Pathology, Research and Practice
|December 1, 1989
Summary
This study found that the CD 15 antigen is present in 59% of Hodgkin
Area of Science:
- Oncology
- Immunohistochemistry
- Hematopathology
Background:
- Hodgkin's disease diagnosis relies on histological subtypes.
- CD 15 antigen expression in Hodgkin's disease requires further investigation.
- Understanding prognostic markers is crucial for patient outcomes.
Purpose of the Study:
- To re-evaluate Hodgkin's disease subtypes using the Lukes-Rye classification.
- To determine the frequency of CD 15 antigen expression in Hodgkin's disease.
- To assess the prognostic significance of CD 15 antigen in Hodgkin's disease.
Main Methods:
- Retrospective analysis of 117 Hodgkin's disease cases (1976-1985).
- Histological reclassification using Lukes-Rye criteria.
- Indirect, three-stage immunoperoxidase technique for CD 15 antigen detection on lymph node biopsies.
Main Results:
- 9 cases were reclassified as non-Hodgkin's lymphoma.
- CD 15 antigen was detected in 64 out of 108 Hodgkin's disease cases (59%).
- CD 15 positivity was independent of histological subtype, patient demographics, clinical stage, or symptoms.
Conclusions:
- CD 15 antigen is a frequent marker in Hodgkin's disease.
- CD 15 antigen expression is not linked to specific histological subtypes or clinical factors.
- CD 15 positive Hodgkin's disease cases exhibit a more favorable prognosis.