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Related Concept Videos

Respiratory System Abnormal Finding I: Inspection and Percussion01:30

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Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

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Physical Assessment of the Respiratory Tract II: Inspection01:27

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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

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Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
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Updated: Apr 16, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Early lung function abnormalities in acromegaly.

A Benfante1, A Ciresi, M Bellia

  • 1Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Pneumologia, Università degli Studi di Palermo, via Trabucco 180, 90146, Palermo, Italy.

Lung
|March 12, 2015
PubMed
Summary
This summary is machine-generated.

Acromegaly patients show reduced carbon monoxide diffusing capacity (TLCO) and KCO, indicating early lung parenchyma involvement. Routine inclusion of TLCO testing is recommended for early intervention in acromegaly.

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Area of Science:

  • Pulmonology
  • Endocrinology
  • Medical Imaging

Background:

  • Acromegaly, caused by pituitary growth hormone (GH)-secreting adenomas, leads to elevated GH and insulin-like growth factor I (IGF-I).
  • Respiratory disorders are frequent complications of acromegaly, impacting quality of life and mortality.

Purpose of the Study:

  • To investigate structural and functional lung alterations in patients with acromegaly.
  • To identify early signs of lung involvement in acromegaly.

Main Methods:

  • Enrolled 10 acromegaly patients with confirmed pituitary tumors via MRI.
  • Conducted clinical, lung function, biological, and radiological assessments.
  • Compared findings with 10 age-matched healthy controls.

Main Results:

  • No significant differences in overall lung function between acromegalic and healthy subjects.
  • Significantly lower diffusing capacity for carbon monoxide (TLCO) and KCO in acromegalics (p=0.04 and p=0.02, respectively).
  • No correlation found between lung function parameters and disease duration, GH/IGF-I levels, or HRCT findings.

Conclusions:

  • Lung function tests, specifically TLCO and KCO, can detect early lung parenchyma involvement in acromegaly.
  • These findings suggest routine inclusion of carbon monoxide diffusing capacity testing for early intervention in acromegaly patients.