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Deep brain stimulation in tinnitus: current and future perspectives.

J V Smit1, M L F Janssen2, H Schulze3

  • 1Department of Ear Nose and Throat/Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

Brain Research
|March 12, 2015
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) shows promise for treating chronic tinnitus, a phantom ringing in the ears affecting millions. Research suggests DBS could counteract the central neural hyperactivity underlying this condition.

Keywords:
Deep brain stimulationNeuromodulationPathophysiologyReviewTinnitusTreatment

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Area of Science:

  • Neuroscience
  • Otolaryngology
  • Neurosurgery

Background:

  • Chronic tinnitus, or ringing in the ears, affects up to 15% of adults, imposing a significant socio-economic burden.
  • Current treatments for tinnitus are limited, lacking substantial efficacy in reducing the phantom sound perception.
  • Recent research has shifted focus from peripheral to central mechanisms in tinnitus pathophysiology, identifying abnormal neural activity in auditory and non-auditory brain regions.

Purpose of the Study:

  • To review potential brain targets for deep brain stimulation (DBS) as a novel therapeutic approach for chronic tinnitus.
  • To explore the applicability of DBS in counteracting pathological neural activity associated with tinnitus.
  • To discuss preclinical and clinical evidence supporting DBS for tinnitus treatment.

Main Methods:

  • Review of preclinical studies investigating neural mechanisms in tinnitus.
  • Analysis of clinical case studies on deep brain stimulation for tinnitus.
  • Discussion of potential subcortical and cortical brain targets for DBS.

Main Results:

  • Evidence suggests increased spontaneous activity, neuronal bursting, and synchrony in subcortical and auditory cortical regions in tinnitus patients.
  • Deep brain stimulation (DBS) has a proven track record in treating other neurological disorders like Parkinson's disease.
  • Preclinical and clinical data indicate potential efficacy of DBS in modulating neural activity relevant to tinnitus perception.

Conclusions:

  • Deep brain stimulation (DBS) presents a promising therapeutic avenue for chronic tinnitus by targeting aberrant neural activity.
  • Further research and clinical trials are warranted to establish optimal DBS targets and parameters for tinnitus.
  • DBS offers a potential solution for tinnitus where current treatments are insufficient, addressing the central mechanisms of the condition.