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Updated: Apr 16, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
[Therapy of overactive bladder (OAB)]
1Klinik für Urologie und Kinderurologie, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland, Martin.Kurosch@kgu.de.
Overactive bladder (OAB) affects 17% of Europeans, causing stress and healthcare costs. Recent research offers new treatments, including medications and surgical options, to manage OAB symptoms effectively.
Area of Science:
- Urology
- Pharmacology
- Pathophysiology
Context:
- Overactive bladder (OAB) is a prevalent condition affecting 17% of the European population.
- OAB presents with or without incontinence, significantly impacting patients' psychological well-being and incurring substantial healthcare costs.
- Etiology involves complex myogenic, urothelial, and neurogenic factors leading to tissue changes.
Purpose:
- To review recent advancements in understanding and treating overactive bladder.
- To highlight new therapeutic agents and approaches for OAB management.
- To emphasize the continued importance of non-pharmaceutical and surgical interventions.
Summary:
- Recent research has improved pathophysiological models for OAB.
- New pharmacological agents are increasingly utilized alongside traditional therapies for OAB.
- Non-pharmaceutical interventions and surgical techniques remain crucial components of OAB treatment.
Impact:
- Improved understanding of OAB pathophysiology.
- Expanded therapeutic options for OAB patients.
- Potential for reduced patient distress and healthcare expenditure associated with OAB.
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