Effect of beta-receptor blockers on uterine contractility in a puerperal model

beta-receptor blockers are increasingly used in the treatment of pregnancy-induced hypertension. Hitherto an oxytocic effect on the myometrium could not be excluded. We investigated the effect of 0.8 resp 1.6 mg pindolol on uterine activity in a double blind study in comparison with a placebo group, using a puerperal model. A "paradoxical" decline in uterine activity could be demonstrated, speaking in favor of a further propagation of beta-blockers in obstetric practice.