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Saving more teeth-a case for personalized care.

Alexandre R Vieira1, Katelyn M Hilands2, Thomas W Braun3

  • 1Department of Oral Biology, 614 Salk Hall, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA. arv11@pitt.edu.

Journal of Personalized Medicine
|March 12, 2015
PubMed
Summary
This summary is machine-generated.

Older patients with more risk factors like diabetes, smoking, and IL1 gene variations face greater tooth loss. Increased preventive care is recommended for those with multiple risk factors to reduce future tooth loss.

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Area of Science:

  • Oral health research
  • Genetics and personalized medicine
  • Public health and preventive dentistry

Background:

  • Identified key risk factors for tooth loss including tobacco use, diabetes, IL1 gene variations, and inflammatory conditions.
  • Hypothesized that individuals with a higher number of risk factors would experience greater tooth loss.

Purpose of the Study:

  • To investigate the association between specific risk factors and tooth loss in a large patient cohort.
  • To determine if the number of risk factors correlates with the extent of tooth loss.

Main Methods:

  • Analyzed DNA samples from 881 individuals for IL1α and IL1β gene polymorphisms (rs1800587, rs1143634).
  • Assessed tooth loss status using dental records and clinical data from 4137 subjects.
  • Employed genetic association analysis (PLINK), chi-square, Mann-Whitney U, and ANOVA tests for statistical significance.

Main Results:

  • Tooth loss increased significantly with age across all identified risk factors (p = 4.07E-13).
  • A higher number of risk factors was significantly associated with increased tooth loss (p = 0.006).
  • Specific risk factors linked to greater tooth loss included age, diabetes, tobacco use, IL1 positive status, and cardiovascular disease.

Conclusions:

  • Older individuals and those with multiple risk factors exhibit higher rates of tooth loss.
  • Recommends enhanced preventive dental care strategies for patients with accumulated risk factors to mitigate future tooth loss.