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5-Hydroxytryptamine (serotonin) 2A receptor gene polymorphism is associated with schizophrenia
Subash Padmajeya Sujitha, Asha Nair, Moinak Banerjee
1School of Biosciences & Technology, VIT University, Vellore, India.
The Indian Journal of Medical Research
|March 12, 2015
Summary
This study found a significant association between specific serotonin receptor 2A gene single nucleotide polymorphisms (SNPs) and schizophrenia in the Tamil population. These findings highlight the importance of ethnicity in schizophrenia genetics.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Schizophrenia is a heritable neuropsychiatric disorder with complex genetic underpinnings.
- Previous genetic association studies have yielded diverse results.
- Identifying specific genetic markers for schizophrenia pathophysiology remains a challenge.
Purpose of the Study:
- To investigate the association between single nucleotide polymorphisms (SNPs) in the serotonin receptor 2A (5HT2A) gene and schizophrenia.
- To analyze these associations within the Tamil-speaking population of South India.
Main Methods:
- Genotyping of candidate SNPs (rs6311 and rs6313) in 266 schizophrenia cases and 272 controls using PCR, RFLP, and sequencing.
- Statistical analysis of SNP data and gene frequencies.
- Linkage disequilibrium (LD) analysis.
Main Results:
- Significant association found between serotonin receptor 5HT2A gene polymorphisms and schizophrenia.
- Higher frequencies of GG (rs6311) and CC (rs6313) genotypes observed in patients compared to controls (P<0.05).
- Significant linkage disequilibrium (LD) between rs6311 and rs6313 genotype frequencies.
Conclusions:
- The study confirms an association between 5HT2A gene SNPs (rs6311 and rs6313) and schizophrenia.
- HapMap analysis indicated unique genotype distribution in the Tamil population compared to global populations.
- Ethnicity-specific studies are crucial for a better understanding of schizophrenia genetics.
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