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A Murine Model of Group B Streptococcus Vaginal Colonization
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Screening and management of maternal colonization with Streptococcus agalactiae: an Italian cohort study

Carmen De Luca1, Natalina Buono1, Vincenzo Santillo2

  • 1a Department of Obstetrics and Gynaecology , Policlinico A. Gemelli, Catholic University of Sacred Heart , Rome , Italy .

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|March 12, 2015
PubMed

Insights

Group B Streptococcus (GBS) screening and intrapartum antibiotic prophylaxis (IAP) are crucial for preventing infant infections. Inadequate screening and IAP in this study led to increased early-onset GBS disease in newborns.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Health
  • Infectious Disease Prevention

Background:

  • Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis.
  • Intrapartum antibiotic prophylaxis (IAP) effectively prevents GBS transmission to newborns.
  • CDC guidelines recommend GBS screening via vaginal and rectal cultures at 35-37 weeks gestation.

Purpose of the Study:

  • To evaluate the adherence to GBS screening and IAP guidelines.
  • To assess the impact of screening and IAP on neonatal outcomes.

Main Methods:

  • Retrospective analysis of 535 women admitted for delivery at Cardarelli Hospital.
  • Evaluation of GBS screening completion, colonization rates, IAP indications, and execution.
  • Assessment of neonatal outcomes.

Main Results:

  • Only 51.5% of women underwent correct GBS screening.
  • 30.2% of women were colonized with GBS.
  • 50% of women with IAP indications received adequate treatment.

Conclusions:

  • Inadequate GBS screening and IAP contribute to increased early-onset GBS disease in newborns.
  • Routine vaginal and rectal GBS screening at 35-37 weeks gestation is essential.
  • Public health initiatives for surveillance and education are needed to reduce neonatal GBS infections.
Abstract

Keywords:
Early-onset diseaseGBSStreptococcus agalactiaeintrapartum care

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