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Plasma levels of peroxisome proliferator-activated receptors (PPARs) change during migraine attacks. PPARα and PPARβ/δ increase, while PPARγ decreases, indicating their role in migraine pathogenesis.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Genetics

Background:

  • Migraine is a complex neurological disorder.
  • Peroxisome proliferator-activated receptors (PPARs) are implicated in various physiological processes.
  • Understanding PPARs' role in migraine is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate plasma PPARs levels in migraine patients.
  • To analyze PPARs changes during attack and attack-free periods.
  • To examine PPARs levels in relation to migraine subtypes (with and without aura).

Main Methods:

  • Enzyme-linked immunoassay (ELISA) was used to measure plasma PPARs levels.
  • 227 migraine patients were divided into attack and attack-free groups.
  • 100 healthy individuals served as controls.

Main Results:

  • PPARα and PPARβ/δ levels were significantly higher during migraine attacks compared to attack-free periods and controls.
  • PPARγ levels were significantly lower during attacks.
  • No significant differences in PPARs levels were observed between migraine with aura and without aura subtypes.

Conclusions:

  • PPARs play a role in the pathogenesis of migraine.
  • The presence or absence of aura does not significantly affect plasma PPARs levels.