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Lymphocyte gamma-glutamyl transferase activity in Behçet's disease
A Pabuçcuoğlu1, A Karan, K Andaç
1Department of Biochemistry, Ege University, Bornova, Izmir, Turkey.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1989
Summary
Gamma-glutamyl transferase (GGT) activity in peripheral blood lymphocytes was significantly lower in Behçet
Area of Science:
- Biochemistry
- Immunology
- Cell Biology
Background:
- Behçet's disease is a rare multi-system inflammatory disorder.
- Gamma-glutamyl transferase (GGT) is a membrane-bound enzyme involved in various cellular processes.
Purpose of the Study:
- To investigate the activity of GGT in peripheral blood lymphocytes (PBL) of patients with Behçet's disease.
- To determine if GGT activity is altered in Behçet's disease.
Main Methods:
- Collected peripheral blood lymphocytes (PBL) from Behçet's disease patients and healthy controls.
- Measured GGT enzyme activity in isolated lymphocytes.
Main Results:
- Lymphocyte GGT activity was significantly lower in patients with Behçet's disease compared to controls (p < 0.01).
Conclusions:
- Altered GGT activity in lymphocytes may be linked to membrane abnormalities in Behçet's disease patients.
- This finding suggests a potential role for GGT in the pathophysiology of Behçet's disease.