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[A case of primary micropapillary carcinoma of the jejunum]
Anna Seki1, Masao Yoshioka, Shunsuke Saito
1Department of Medicine, Okayama Saiseikai General Hospital.
Abstract:
Micropapillary carcinoma (MPC) has been recently reported as a variant of invasive breast carcinoma. MPC is also known to be an aggressive variant of adenocarcinoma, and it is associated with poor prognosis and a high propensity for lymphovascular invasion and lymph node metastases. MPC of the breast, urinary bladder, and lung has been reported relatively frequently; however, there have been few reports on gastrointestinal MPC. Furthermore, MPC of the small bowel has not been reported yet. Here we report a case of MPC of the jejunum. A female septuagenarian was admitted because of anorexia and weight loss. We established a diagnosis of primary jejunal cancer and resected the duodenum and a part of the jejunum. Histologically, the tumor consisted of adenocarcinoma with moderate to poor differentiation. Among the carcinoma cells, approximately 10% formed small papillary neoplastic cell clusters surrounded by clear spaces, suggesting a diagnosis of MPC. We present the details of the case along with a review of relevant literature.
Insights
Micropapillary carcinoma (MPC), an aggressive cancer variant, was identified in the jejunum, a location previously unreported for this subtype. This case highlights the need for awareness of MPC in the small intestine.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Micropapillary carcinoma (MPC) is an aggressive adenocarcinoma variant linked to poor prognosis and metastasis.
- While reported in breast, lung, and bladder, gastrointestinal MPC is rare.
- MPC of the small bowel has not been previously documented.
Observation:
- A septuagenarian female presented with anorexia and weight loss.
- Diagnosis of primary jejunal cancer was established.
- Surgical resection of the duodenum and jejunum was performed.
Findings:
- Histological examination revealed adenocarcinoma with moderate to poor differentiation.
- Approximately 10% of carcinoma cells formed small papillary clusters within clear spaces, indicative of MPC.
- This represents the first reported case of jejunal micropapillary carcinoma.
Implications:
- This case expands the known anatomical sites for micropapillary carcinoma.
- It underscores the importance of considering MPC in small bowel adenocarcinoma diagnoses.
- Further research is warranted to understand the behavior and treatment of jejunal MPC.
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