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TRAIL modulates the immune system and protects against the development of diabetes

Fleur Bossi1, Stella Bernardi1, Giorgio Zauli2

  • 1Department of Medical, Surgical, and Health Sciences, University of Trieste, Cattinara University Hospital, Strada di Fiume 447, 34100 Trieste, Italy.

Journal of Immunology Research
|March 12, 2015
PubMed

Insights

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has complex roles beyond cancer, potentially impacting diabetes development. This review explores TRAIL

Area of Science:

  • Immunology
  • Cell Biology
  • Endocrinology

Background:

  • Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a TNF superfamily protein.
  • TRAIL primarily induces apoptosis in tumor, infected, or transformed cells.
  • TRAIL's functions in non-transformed cells, including its role in diabetes, are less understood.

Purpose of the Study:

  • To review the biological actions of TRAIL.
  • To examine TRAIL's effects on the immune system.
  • To assess TRAIL's protective role against diabetes.

Main Methods:

  • Literature review of studies on TRAIL.
  • Analysis of TRAIL's biological functions.
  • Evaluation of TRAIL's impact on immune responses.
  • Synthesis of evidence regarding TRAIL and diabetes.

Main Results:

  • TRAIL has diverse biological actions.
  • TRAIL influences immune system activity.
  • Evidence suggests TRAIL may protect against diabetes development and progression.

Conclusions:

  • TRAIL's role in non-transformed cells requires further investigation.
  • TRAIL's immunomodulatory effects are significant.
  • TRAIL presents a potential therapeutic target for diabetes.

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