Related Experiment Video
Updated: Apr 16, 2026
07:11
Treatment of Facial Deformities using 3D Planning and Printing of Patient-Specific Implants
Published on: May 23, 2020
8.1K
Gorham disease of the mandible.
Su-Feng Zhao1, Yu-Xin Wang, Xu-Dong Yang
1From the Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Medical School, Nanjing University, Nanjing, People's Republic of China.
The Journal of Craniofacial Surgery
|March 12, 2015
Summary
Gorham disease causes progressive bone loss, often affecting the mandible. This case highlights ongoing mandibular bone loss despite surgical reconstruction, emphasizing the need for careful diagnosis and monitoring.
Area of Science:
- Dentistry
- Orthopedics
- Rare Diseases
Background:
- Gorham disease, also known as massive osteolysis, is a rare idiopathic condition characterized by progressive bone resorption.
- The mandible is frequently affected in the maxillofacial region, presenting unique diagnostic and management challenges.
Observation:
- A 46-year-old male patient with Gorham disease involving the mandible is presented.
- The patient underwent surgical intervention including lower right mandibular osteotomy and reconstruction with a phased titanium plate.
Findings:
- Despite surgical intervention, the patient exhibited continued mandibular bone loss.
- The osteolysis progressed to the contralateral side of the mandible, indicating the aggressive nature of the disease.
Implications:
- Massive osteolysis of the mandible requires differentiation from other conditions like osteomyelitis and tumors.
- Effective management necessitates improved diagnostic strategies and long-term patient follow-up.
Related Concept Videos
01:12The Hyoid Bone
7.0K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
7.0K
01:28Disorders of the Skeletal Muscle
2.4K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.4K
01:29Bone Disorders
8.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.7K