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Does 18F-FDG PET/MRI reduce the number of indeterminate abdominal incidentalomas compared with 18F-FDG PET/CT?

Benedikt M Schaarschmidt1, Johannes Grueneisen, Philipp Heusch

  • 1aDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University of Dusseldorf, Dusseldorf bDepartment of Diagnostic and Interventional Radiology and Neuroradiology cDepartment of Nuclear Medicine, Medical Faculty, University of Duisburg-Essen, Essen, Germany.

Nuclear Medicine Communications
|March 12, 2015
PubMed
Abstract

Insights

(18)F-fluorodeoxyglucose (FDG) PET/MRI detects more abdominal incidentalomas than PET/CT. This advanced imaging technique significantly reduces indeterminate findings, improving diagnostic clarity for abdominal incidentalomas.

Area of Science:

  • Radiology
  • Nuclear Medicine
  • Oncology

Background:

  • Incidentalomas in abdominal organs are frequently discovered during radiological examinations.
  • Distinguishing benign from malignant incidentalomas can be challenging with conventional imaging.

Purpose of the Study:

  • To compare the efficacy of simultaneous (18)F-fluorodeoxyglucose ((18)F-FDG) PET/MRI versus (18)F-FDG PET/CT in reducing indeterminate abdominal incidentalomas.
  • To leverage the superior soft-tissue contrast and diverse sequences of PET/MRI for improved characterization.

Main Methods:

  • Retrospective analysis of 173 patients who underwent contrast-enhanced (18)F-FDG PET/CT.
  • Two readers evaluated PET/CT and PET/MRI datasets for incidentalomas in abdominal organs.
  • Findings were classified as most likely malignant, indeterminate, or most likely benign.

Main Results:

  • (18)F-FDG PET/MRI identified more incidentalomas (n=635) compared to PET/CT (n=407).
  • Significantly fewer indeterminate findings were observed with PET/MRI (n=27) versus PET/CT (n=91).
  • PET/MRI clarified 70 indeterminate lesions from PET/CT as likely benign.

Conclusions:

  • Simultaneous (18)F-FDG PET/MRI is superior to PET/CT in detecting abdominal incidentalomas.
  • (18)F-FDG PET/MRI significantly decreases the proportion of indeterminate findings, enhancing diagnostic confidence.

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