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Hidradenitis suppurativa and metabolic syndrome: a comparative cross-sectional study of 3207 patients
G Shalom1,2, T Freud3, I Harman-Boehm2,4
1Department of Dermatology and Venereology, Soroka Medical Center, P.O.B. 151, Beer-Sheva, 84101, Israel.
Insights
Hidradenitis suppurativa (HS) is linked to metabolic syndrome and its components like diabetes and obesity. Early screening for metabolic issues is recommended for HS patients, even younger ones.
Area of Science:
- Dermatology
- Metabolic Health
- Epidemiology
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition.
- The relationship between HS and metabolic syndrome is not fully understood.
Purpose of the Study:
- To investigate the association between HS and metabolic syndrome.
- To evaluate the link between HS and individual metabolic syndrome components.
Main Methods:
- Cross-sectional study utilizing data from Clalit Health Services in Israel.
- Metabolic syndrome defined by presence of diabetes, hyperlipidaemia, hypertension, or obesity.
- Multivariate logistic regression analysis adjusted for confounders.
Main Results:
- Significant association found between HS and metabolic syndrome (OR 1.61).
- HS patients showed increased odds for diabetes (OR 1.41), obesity (OR 1.71), hyperlipidaemia (OR 1.14), and hypertension (OR 1.19).
Conclusions:
- A clear association exists between HS and metabolic syndrome and its components.
- Clinicians should consider screening HS patients for undiagnosed metabolic conditions.
- Targeted screening is advised for early detection and management.
Background:
Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory skin disease.
Objectives:
To evaluate the association between HS and metabolic syndrome and its component morbidities in a large, community-based cohort of patients with HS, using the database of Clalit Health Services, the largest public healthcare provider in Israel.
Methods:
A cross-sectional study was performed. Metabolic syndrome was defined as the presence of at least three of the following conditions: diabetes, hyperlipidaemia, hypertension and obesity. The association between HS and metabolic syndrome was assessed by a multivariate logistic regression model, adjusting for age, sex, diabetes, hypertension, hyperlipidaemia, obesity and smoking status.
Results:
The study included 3207 patients with HS (general frequency of 0·07%) diagnosed by a dermatologist in primary-care centres, and 6412 age- and sex-matched control patients without HS. HS was significantly associated with metabolic syndrome [odds ratio (OR) 1·61, 95% confidence interval (CI) 1·36-1·89], diabetes (OR 1·41, 95% CI 1·19-1·66), obesity (OR 1·71, 95% CI 1·53-1·91), hyperlipidaemia (OR 1·14, 95% CI 1·02-1·28) and hypertension (OR 1·19, 95% CI 1·03-1·38).
Conclusions:
We found an association between HS and diabetes, hyperlipidaemia, obesity, hypertension and metabolic syndrome among a large community-based cohort of patients with HS. Clinicians should take into account that patients with HS may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.
