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Adiponectin in asthma: implications for phenotyping
Ersilia Nigro1, Aurora Daniele, Olga Scudiero
1Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Seconda Universita degli Studi di Napoli, CEINGE-Biotecnologie Avanzate Scarl, Via Gaetano Salvatore 486, 80145 Napoli, Italy. daniele@ceinge.unina.it.
Current Protein & Peptide Science
|March 12, 2015
Summary
Adiponectin, a protein linked to obesity, plays a role in lung inflammation and asthma. This review explores how adiponectin influences various asthma phenotypes, offering insights into disease mechanisms and potential treatments.
Area of Science:
- Pulmonary Medicine
- Endocrinology
- Immunology
Background:
- Asthma is a complex inflammatory airway disease with diverse phenotypes, including those associated with obesity.
- Obesity is a significant risk factor and predictor of poor prognosis in asthma, yet underlying biological mechanisms remain under-investigated.
- Adiponectin, a key adipokine, has emerged as a crucial factor in lung physiology and pathology.
Purpose of the Study:
- To review the existing literature on the impact of adiponectin on the expression of specific clinical asthma phenotypes.
- To explore the role of adiponectin and its receptors in the context of obesity-associated asthma.
Main Methods:
- Literature review of studies investigating adiponectin levels and its receptors in asthma patients and models.
- Analysis of research linking adiponectin pathways to clinical features of asthma phenotypes.
- Examination of the expression of adiponectin receptors (AdipoR1, AdipoR2, T-cadherin) in lung cells.
Main Results:
- Adiponectin levels and its receptor expression are modulated in asthma patients and mouse models.
- Larger adiponectin oligomers exhibit anti-inflammatory effects relevant to lung health.
- Evidence suggests a link between adiponectin signaling and specific asthma phenotypes, particularly those related to obesity.
Conclusions:
- Adiponectin and its receptors are involved in the pathophysiology of asthma.
- Understanding adiponectin's role may help in identifying asthma phenotypes and guiding therapeutic strategies.
- Further research into adiponectin pathways could reveal novel targets for managing obesity-related asthma.
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