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Published on: November 30, 2022
[Safety nonsteroidal antiinflammatory drugs]
Teodoro Julio Oscanoa-Espinoza1
1Sección de Farmacología, Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Instituto de Investigaciones de la Facultad de Medicina de la Universidad San Martin de Porres, Lima, Perú. tjoscanoae@gmail.com.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used globally. This review examines NSAID safety, focusing on gastrointestinal, cardiac, and kidney toxicity risks.
Area of Science:
- Pharmacology
- Toxicology
- Internal Medicine
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently consumed medications worldwide.
- Selection of a specific NSAID involves considerations of efficacy, safety, cost, and patient suitability.
- Comprehensive safety reviews are crucial due to the widespread use of NSAIDs.
Purpose of the Study:
- To analyze the safety profile of Nonsteroidal anti-inflammatory drugs (NSAIDs).
- To evaluate NSAID-associated risks concerning gastrointestinal, cardiovascular, and renal systems.
- To provide a consolidated overview of NSAID-related toxicity.
Main Methods:
- Literature review of existing studies on NSAID safety.
- Analysis of data pertaining to gastrolesivity, cardiotoxicity, and nephrotoxicity.
- Synthesis of evidence regarding the adverse effects of NSAIDs.
Main Results:
- NSAIDs are associated with significant gastrointestinal risks, including ulcers and bleeding.
- Cardiotoxicity, such as increased risk of myocardial infarction and stroke, is a concern with certain NSAIDs.
- Nephrotoxicity, manifesting as acute kidney injury and chronic kidney disease, can occur with NSAID use.
Conclusions:
- The safety of NSAIDs is a critical consideration, with distinct risks for gastrointestinal, cardiovascular, and renal health.
- Clinicians must carefully weigh the benefits against the risks of NSAIDs for individual patients.
- Further research into safer NSAID alternatives and risk mitigation strategies is warranted.
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